1. CLONIDINE (Cetapres/ Dixarit) dose varies between 0,050 mg twice a day to 0,075 mg 3 times a day. Especially severe flushers find that they need to take it every 8 hours, or they get rebound flushing. I was prescribed this drug by dermatologist and rosacea expert Dr. Tony Chu from London's Hammersmith Hospital, who found it helpful in many of his vascular rosacea patients. It helps with facial flushing in several ways, from what I have understood (although the exact way of action seems not fully understood yet): it acts as a peripheral vascular stabilizer, and flushing is partly due to vasomotor instability. But it also tends to shut down the smaller blood vessels in the extremities (hands, feet and face) to some degree, since it works officially as a blood pressure lowering drug. It widens the big arteries in the centre of your body and around your heart, so that the blood pressure in the rest of the arteries goes down. Therefore more blood is drawn away from the extremities (hands, feet and face) and the face gets less red, flushed and therefore it burns less. It gives the facial blood vessels some (well deserved) rest and that seems to turn around the severity of the rosacea for many. Clonidine also relaxes the smooth muscle of blood vessels, causing them to widen, or dilate. This reduces the pressure of blood flow through the artery. It's calming affect is also used to treat anxiety disorders, hot flashes, flushing and sleeplessness. Clonidine can make your mouth dry cause severe drowsiness. This medication shouldn’t be used every now and then, but structurally and daily, for a longer period of time preferably, as the full effects of it tend to accumulate over time and it might give rebound flushing if you stop with it suddenly. I had normal blood pressure to start with and I had a short drop of blood pressure (but within the safe range) for a few months and then my body adjusted it, as Dr Chu had predicted and I have now a steady blood pressure of 110 over 80. Clonidine can also be used to treat hot flashes. Because it is a non hormonal treatment, women with a history of breast cancer can use it without increasing the risk of further cancer cell growth (as in the case of estrogen treatment). *Possible side-effects: -cold hands and feet in the winter: in my experience these symptoms are mild ( I have been diagnosed with Raynaud´s syndrome) and for many they are non existent. -dizziness/tiredness: this happens mainly in the first weeks/months of using, when the body needs to adjust. In time it usually wears off, so you will need to give it some time in this respect as well. -Dry mouth: tends to wear off as well, but Clonidine can dry out your membranes (dry mouth, dryer eyes), so you should drink plenty when you use it.